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Captopril tablets, USP are a specific competitive inhibitor of angiotensin I-converting
enzyme (ACE), the enzyme responsible for the conversion of angiotensin I to
angiotensin II.Hypertension: Captopril tablets, USP are indicated for the treatment of hypertension.
In using captopril, consideration should be given to the risk of
neutropenia/agranulocytosis (see WARNINGS).
Captopril may be used as initial therapy for patients with normal renal function, in whom
the risk is relatively low. In patients with impaired renal function, particularly those with
collagen vascular disease, captopril should be reserved for hypertensives who have
either developed unacceptable side effects on other drugs, or have failed to respond
satisfactorily to drug combinations.
Captopril is effective alone and in combination with other antihypertensive agents,
especially thiazide-type diuretics. The blood pressure lowering effects of captopril and
thiazides are approximately additive.
Heart Failure: Captopril tablets are indicated in the treatment of congestive heart
failure usually in combination with diuretics and digitalis. The beneficial effect of captopril
in heart failure does not require the presence of digitalis, however, most controlled
clinical trial experience with captopril has been in patients receiving digitalis, as well as
diuretic treatment.

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